Original Contribution Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
نویسندگان
چکیده
1 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 2 Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 3 Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, Newark, NJ. 4 Department of Medicine, School of Medicine, University of Washington, Seattle, WA. 5 Department of Pathology, College of Medicine, University of Vermont, Burlington, VT. 6 Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT. 7 Center on Aging and Health, Schools of Public Health and Medicine, Johns Hopkins University, Baltimore, MD.
منابع مشابه
Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease: Longitudinal Findings from the Heart and Soul Study
BACKGROUND Leukocyte telomere length, an emerging marker of biological age, has been shown to predict cardiovascular morbidity and mortality. However, the natural history of telomere length in patients with coronary artery disease has not been studied. We sought to investigate the longitudinal trajectory of telomere length, and to identify the independent predictors of telomere shortening, in p...
متن کاملThe rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
Telomere length (TL) has been proposed as a marker of mitotic cell age and as a general index of human organismic aging. Short absolute leukocyte telomere length has been linked to cardiovascular-related morbidity and mortality. Our aim was to test whether the rate of change in leukocyte TL is related to mortality in a healthy elderly cohort. We examined a subsample of 236 randomly selected Cau...
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Background: Exercise and consumption of green tea affect the aging process. However, the effect of exercise training combined with green tea extract on leukocyte telomere length, quality of life (QoL) and body composition in aging has so far been unclear and inconsistent. Objective: The aim of the present study was to determine the effectiveness of aerobic training intervention and green tea e...
متن کاملLeukocyte telomere length and cardiovascular disease in the cardiovascular health study.
The telomere length of replicating somatic cells is inversely correlated with age and has been reported to be associated cross-sectionally with cardiovascular disease (CVD). Leukocyte telomere length, as expressed by mean terminal restriction fragment (TRF) length, was measured in 419 randomly selected participants from the Cardiovascular Health Study, comprising a community-dwelling cohort rec...
متن کاملSoda and cell aging: associations between sugar-sweetened beverage consumption and leukocyte telomere length in healthy adults from the National Health and Nutrition Examination Surveys.
OBJECTIVES We tested whether leukocyte telomere length maintenance, which underlies healthy cellular aging, provides a link between sugar-sweetened beverage (SSB) consumption and the risk of cardiometabolic disease. METHODS We examined cross-sectional associations between the consumption of SSBs, diet soda, and fruit juice and telomere length in a nationally representative sample of healthy a...
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